A recent review article in Archives of Internal Medicine, a leading 
scientific medical journal, once again confirms that 
cranberry-containing products prevent urinary tract infections.
The review confirmed that women, suffering from recurrent urinary tract 
infections (UTIs), had almost 50% reduction in incidence. 
For children this percentage was even more striking. Researchers of the 
National Taiwan University, who performed the review, found a reduction 
of 67% of bladder infections. This is important, since benefits of 
prophylactic use of antibiotics in children is found to be small. 
Moreover, prophylactic use of antibiotics results in resistance against 
these antibiotics as well as against other frequently prescribed 
antibiotics, which is of great concern. 
The review included 13 placebo controlled clinical trials examining the 
effect of cranberry-containing products such as cranberry juice (9 
trials) and cranberry supplements (4 trials). 
The cranberry juice groups appeared to benefit more than the groups 
taking cranberry supplements, which can be explained by the effect of a 
greater fluid intake. 
Drinking plenty of water is important to ward of an UTI. 
Compliance of drinking several glasses of cranberry juice each day was 
difficult leading to quite a number of drop-outs in the cranberry juice 
groups. Besides ,a disadvantage of drinking cranberry juice is the sugar
 content of these juices. 
The review supports the consumption of cranberry-containing products for
 preventing UTIs, especially in women and children suffering from 
recurrent UTIs. 
Studies comparing cranberries with the standard therapy for prevention 
of UTIs (antibiotics) were not included in the meta-analysis. Only 
studies comparing cranberries with placebo were included.
Results of studies which did compare cranberries with standard therapy 
(Amsterdam AMC – Dundee) showed similar results in reducing 
recurrent UTIs as the studies included in the meta-analysis (40 to 50%),
 although antibiotics were twice as effective as cranberries in the 
Amsterdam study.
While antibiotics are obviously effective, growing concern has arisen 
about the emerging antibiotic resistance in primary healthcare, which 
can occur within a month after a single cure and can last up to one year
 in cases of more frequent cures.
Furthermore many women worry about the adverse side effects of taking drugs. 
In an editorial article in Future Microbiology  [5] Dr. Suzanne 
Geerlings of the Amsterdam University AMC stated that “premenopausal 
women with recurrent UTIs are commonly recommended to take low-dose 
antibiotics. However, this may lead to resistance of not only the 
causative microorganisms, but also of the indigenous flora”.
In the study of the Amsterdam University with younger women, the number 
of recurrent UTIs in the cranberry group changed from 7 in the year 
before the study to 4.2 in the study year. Almost 25% of the women in 
the cranberry group experienced no UTI at all in the study year.
This was not much different from the 29% of the women in the antibiotic group who remained free of an UTI. 
More information:
In the AMC study a cranberry supplement was used with a special 
production method and composition. For this specific supplement all the 
vital parts of the whole cranberry are used: skin, seeds, pulp, juice 
and fiber. All the active ingredients are present in their natural 
state. 
The patented manufacturing process provides a bioactive protection to 
all parts of the cranberry avoiding destruction by gastric acid. In 
addition, it gives the cranberry concentrate a regulated release. Not 
all available cranberry supplements have these functional 
characteristics.
This study used cranberry specialty Cranaxil supplied by Springfield Nutraceuticals, The Netherlands
Cranaxil cranberry concentrate 500mg.
Available from good health stores, independent drugstore and www.thenutricentre.co.uk. 
The RRP is £13.95 for 30 capsules or £26.95 for 60 capsules. 
Cranaxil cranberry concentrate is safe to take, also by children. 
 cranaxil
 
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