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Alzheimer's Diagnostic Blood Test Now Available in the UK

Advance Tests, a pioneer in advanced diagnostics, today announced the exclusive UK launch of LucentAD Complete, an innovative, multi-marker blood test that provides highly accurate risk classification for amyloid pathology associated with Alzheimer’s Disease.

Developed by Lucent Diagnostics, a commercial brand of Quanterix Corporation, this breakthrough diagnostic test combines several Alzheimer’s-related biomarkers, including p-Tau 217, to enhance early detection in patients with cognitive symptoms. 

This exclusive collaboration between Lucent Diagnostics and Advance Tests allows Advance Tests to deliver the test to patients and healthcare providers in the UK from December 2nd, marking a significant milestone in accessible Alzheimer’s diagnostics.

Key Advantages of LucentAD Complete:

Available Now: Bookings can be made now in the UK for appointments from December 2nd, introducing a biomarker blood test for clinical use for the very first time. Patient samples will be transported securely to the Lucent laboratories in the USA for analysis, with results made available within 15 working days.

High Accuracy: Achieves 90% accuracy in detecting amyloid pathology, in early-stage identification of Alzheimer’s.

Accessible: Priced at £695, LucentAD Complete is a cost-effective alternative to PET imaging and lumbar punctures, which can be significantly more expensive.

Non-Invasive: Requires only a blood sample, eliminating the need for invasive CSF collection and costly imaging procedures, in line with Advance Tests’ mission to make life-saving diagnostics widely accessible.

Reduced Uncertainty: The inclusion of multiple biomarkers in a sophisticated algorithmic model significantly reduces intermediate results, allowing nearly 90% of those being tested to receive a conclusive classification that either rules in or rules out Alzheimer’s Disease, far exceeding the standards set by the Global CEOi BBM Working Group.

The LucentAD Complete test utilizes p-Tau 217 along with additional biomarkers—Aβ42/40, GFAP, and NfL—to improve amyloid detection over single biomarker tests, delivering a result that either rules in or rules out amyloid pathology for approximately 90% of cases. The test meets the Global CEO Initiative on Alzheimer’s Disease’s (CEOi) and the US Alzheimer’s Association (AA) performance standards for plasma-based diagnostic tools, offering an advanced alternative to the current gold standard cerebrospinal fluid (CSF) or PET imaging approaches which are both highly invasive and considerably more expensive.

The test will be available on a private basis, with appointments for testing offered at Advance Tests’ first clinic located on St Thomas Street, beside Guy’s Hospital opposite London Bridge station. Additional clinics are planned for cities across the UK to expand patient access to this transformative diagnostic tool. Appointments can be booked now either directly or by healthcare providers via www.advancetests.com with appointments available from December 2nd 2024.

“We’re proud to exclusively bring LucentAD Complete to the UK, offering healthcare providers and patients a reliable and accessible diagnostic aid that can transform Alzheimer’s care,” said Dr. Simon Worrell, Founder and Chief Medical Officer of Advance Tests. “Our work with Quanterix strengthens our commitment to removing barriers to early diagnosis, enabling timely treatment that could profoundly impact patients’ lives.”

Dr. Karan Jutlla, Head of the Centre for Applied and Inclusive Health Research, University of Wolverhampton, commented on the introduction of LucentAD Complete: “Having access to this sophisticated, non-invasive blood test is a game-changer for early Alzheimer’s diagnosis in the UK. By simplifying diagnostics, we’re helping more patients access critical care sooner, especially as new therapies for early-stage Alzheimer’s are becoming available.”

For more information, visit www.advancetests.com.

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The Dark Side of Relationships: What Drives People to Hurt Those They Claim to Love?

The question of why people commit cruel, heartless acts against their friends or family members—those they are supposed to love and protect—is deeply perplexing.

Even more baffling is their subsequent expectation that the wronged party will forgive them, overlook the harm, and continue the relationship as though nothing happened. 

This pattern of behaviour raises profound questions about human nature, relationships, and the psychology behind such actions.

The Roots of Cruelty: Understanding Motivations

To comprehend why someone might inflict emotional or even physical harm on those closest to them, we need to delve into the complex tapestry of human psychology. There isn’t a one-size-fits-all answer, but several possible motivations and factors could contribute to such behaviour:

Unresolved Trauma and Projection: Often, individuals who act cruelly towards loved ones have unresolved emotional wounds from their past. Whether stemming from childhood abuse, neglect, or other traumatic experiences, these unaddressed feelings can manifest as projection. Rather than dealing with their own pain, they project it onto those closest to them, inflicting the suffering they carry internally. By doing so, they paradoxically regain a sense of control over their unresolved trauma.

Narcissism and Self-Centredness: For some, cruelty is an expression of narcissistic tendencies. These individuals are often driven by an inflated sense of self-importance and a lack of empathy. They might view others as extensions of themselves, existing solely to fulfil their needs and desires. When a family member or friend fails to meet these expectations, the narcissistic individual may lash out cruelly, feeling justified in their actions because they perceive their own needs as more important.

Control and Manipulation: At times, cruelty is wielded as a tool for control. By belittling, criticising, or otherwise harming a friend or family member, the perpetrator seeks to establish dominance in the relationship. They may feel empowered when the other person is weakened emotionally or psychologically. This can also lead to the insidious cycle of abuse where the wrongdoer expects the wronged person to stay, convincing them that leaving is not an option or that they are to blame for the mistreatment.

Insecurity and Fear of Abandonment: Oddly, cruelty can sometimes stem from a deep-seated fear of abandonment. Insecure individuals may believe that by hurting someone, they can prevent that person from leaving them. The twisted logic here is that if a loved one is broken down enough or made to feel unworthy, they will stay out of fear that no one else will want them. This creates a toxic cycle where cruelty is used as a misguided attempt to ensure loyalty.

Desensitisation and Lack of Empathy: In some cases, individuals have become so desensitised to the feelings of others that they no longer recognise the harm they cause. Whether through upbringing, societal conditioning, or personal choice, they may have lost the ability to empathise. To them, the feelings of others are inconsequential, and so they feel no guilt or remorse for the pain they inflict.

The Thrill of Power and Sadistic Enjoyment: For a small percentage of people, cruelty brings a thrill. This is not to say that they are necessarily sadistic in a pathological sense, but there may be a certain pleasure derived from wielding power over someone else's emotions. This kind of behaviour often surfaces in people who have felt powerless in other areas of their lives; hurting those who are close becomes a means of regaining a sense of potency.

Why Do They Expect Forgiveness?

After hurting their loved ones, why do such individuals often expect—or even demand—that the wronged person stay in the relationship? There are several psychological explanations for this perplexing behaviour:

Cognitive Dissonance: Cognitive dissonance is the mental discomfort experienced when someone holds two contradictory beliefs or behaviours. After committing a hurtful act, the perpetrator may attempt to alleviate this discomfort by convincing themselves that what they did wasn't really that bad or that the other person deserved it. By expecting the wronged party to forgive them, they attempt to "reset" the relationship, avoiding the need to confront their own misdeeds.

Entitlement and Lack of Accountability: Many people who hurt others feel a sense of entitlement that makes them believe they are above the normal rules of decency. They may see themselves as deserving forgiveness without having to put in any effort to atone for their actions. They are used to shifting the blame or rewriting the narrative to present themselves as the victim.

Dependency and Fear of Consequences: Perpetrators who are heavily reliant on the relationship may expect the wronged person to stay because they cannot imagine life without them. They may fear the consequences of their own actions, such as social ostracism or personal loneliness, more than they regret the pain they caused. In this case, their need for the relationship outweighs any genuine remorse.

Emotional Manipulation and Gaslighting: Sometimes, the expectation for the wronged person to stay is rooted in emotional manipulation. The wrongdoer may use gaslighting tactics, making the victim doubt their own reality, or convincing them that they are overreacting. By making the victim feel responsible for the stability of the relationship, they pressure them into staying despite the hurt caused.

The Consequences of Staying in Toxic Relationships

When individuals choose to stay in relationships where they are mistreated, it often leads to a cycle of abuse that can be difficult to break. While forgiveness and second chances are admirable qualities, there is a point where it becomes self-destructive to stay in a toxic situation. Here are some consequences that can arise:

Erosion of Self-Esteem: Remaining in a relationship with someone who regularly hurts you can erode your self-worth over time. The constant barrage of negativity, criticism, or manipulation can make you start to believe that you deserve the treatment you’re receiving.

Emotional Burnout and Mental Health Issues: Prolonged exposure to toxic relationships can lead to severe anxiety, depression, and emotional exhaustion. The stress of constantly walking on eggshells or trying to appease someone who never seems satisfied can take a significant toll on your mental health.

Isolation from Support Networks: Often, abusers will try to isolate their victims from friends and family to maintain control. This can leave the victim feeling even more dependent on the toxic relationship, perpetuating the cycle of abuse.

Breaking Free: Choosing Self-Respect Over Toxic Loyalty

If you find yourself in a relationship where someone consistently hurts you and expects you to remain loyal despite the pain, it may be time to reassess the situation. Self-respect, personal boundaries, and emotional well-being should not be sacrificed in the name of loyalty, especially when it is one-sided.

Leaving a toxic relationship can be incredibly difficult, especially when emotional ties, shared history, or even children are involved. However, it is crucial to remember that your self-worth is not determined by how well you can endure mistreatment. Choosing to prioritise your mental and emotional health is a courageous step towards reclaiming your life.

Ultimately, while people may have different reasons for their cruel actions, it is never your responsibility to excuse, justify, or remain in the presence of someone who consistently brings you pain. The most empowering act of self-love is knowing when to walk away.